Figure 1 Co-founder

One of the refrains I have heard a lot is that novel therapies don’t hurt, also known as the “what have you got to lose” strategy. Here are two X-rays that demonstrate the—often unpredictable—harm that comes from novel adjuncts. This patient was admitted to the ICU with COVID pneumonia a few weeks ago and due to a very high D-dimer level, empiric anticoagulation was initiated. The night prior to extubation, the patients oxygen saturation plummeted, fresh blood appeared in the ventilator tubing, and the second X-ray was obtained.